Efforts to Generate a Male Contraception Just by Prevention of Sperm Motility Acquirement in Epididymis Without Influencing the Physiology of Spermatogenesis: Yet Still a Little Far Goal

Kulvinder Kochar Kaur^1*, Gautam Allahbadia², Mandeep Singh^3
1Scientific Director, Dr. Kulvinder Kaur Centre For Human Reproduction, Jalandhar, Punjab, India
²Scientific Director, Ex-Rotunda - A Centre for Human Reproduction, Mumbai, India
³Consultant Neurologist, Swami Satyanand Hospital, Jalandhar, Punjab, India

Correspondence to: Kulvinder Kochar Kaur, Scientific Director, Dr. Kulvinder Kaur Centre For Human Reproduction, Jalandhar, Punjab, India; E-mail: kulvinder.dr@gmail.com
Received date: June 1, 2021; Accepted date: June 14, 2021; Published date: June 21, 2021
Citation: Kaur KK, Allahbadia G, Singh M (2021) Efforts to Generate a Male Contraception Just by Prevention of Sperm Motility Acquirement in Epididymis Without Influencing the Physiology of Spermatogenesis: Yet Still a Little Far Goal. J Obst Gynecol Surg 2(1): pp. 1-3. doi: 10.52916/jogs214012
Copyright: ©2021 Kaur KK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Abstract

In view of the world population escalating at an alarming rate anticipated population will reach 9.8 billion by 2050. In contrast to female contraceptive measures male contraceptive methods are relatively negligible. Maximum researchers have concentrated on generation of male contraceptive methods by trying to modulate hormones but had to abandon this strategy as the pharmaceutical companies were not happy in view of marked adverse actions. Maximum nonhormonal strategies in research concentrate on spermatogenesis repression or reversible physical barriers. Sperm motility represents one of the maximum significant markers of semen quality as it is necessary for sperm motion appropriately in the female reproductive tract for it to arrive intricately towards the egg as well as fertilize it.

The group of Vijayraghavan S, et al. have been concentrating on generation of a male contraceptive by utilization of targeting sperm motility at epididymal level by extensively studying the regulation of flaggelar protein motion by various subunits like Protein Phosphatase 1 (PP1), Protein Phosphatase Inhibitor-2 (PPPIR2), its phosphorylation by Glycogen Synthase Kinase-3 (GSK3), A kinase anchor protein 4(AKAP4). Recently they attempted to generate a bioportide that could simulate binding of the anchor protein AKAP4 that had been earlier revealed as a PPγ2 interactor in human sperm,that are implicated in sperm motility .Unfortunately that did not abolish sperm motility completely .This seemed to be surprising as PP1/ PPPIR2crosstalk seems to be central in regulation of sperm motility. Thus Silva et al., pointed that evaluation of the probable part of PPPIR7 as well as PPPIR11 in the manipulation of sperm motility in men might be the aim of future studies that needs to be continued to get more insight in this field.

Keywords:

Male contraception, Biopeptides, Protein Phosphatase Inhibitor-2 (PPPIR2), Protein Phosphatase-1 (PP1), AKAP4